Session 6: Pediatrics/Foot and Ankle
Onsdag den 25. oktober
11:00-12:00
Lokale: Helsinki/Oslo
Chairmen: Bjarne Møller Madsen og Jeannette Penny
51. PRP-enriched Allogenic Cartilage Decreases Risk of Bone Bridge Formation after Physeal Injury in an Experimental Porcine Model
Ahmed Abdul-Hussein Abood, Bjarne Møller-Madsen, Juan Manuel Shiguetomi-Medina, Morten Lykke Olesen, Hans Stødkilde-Jørgensen, Casper Bindzus Foldager, Ole Rahbek
Children's Orthopaedics, Aarhus University Hospital; Children's Orthopaedics, Aarhus University Hospital; Orthopaedic Research Laboratory, Aarhus University Hospital; Orthopaedic Research Laboratory, Aarhus University Hospital; MR Center, Aarhus University Hospital; Orthopaedics, Aarhus University Hospital; Children's Orthopaedics, Aarhus University Hospital
Background: The use of biological material is currently
explored for prevention of bone bridge
formation, however no novel treatment
technique has been proposed. An
improvement in current clinical practice can
be of great value to the affected children.
Purpose / Aim of Study: To investigate the efficacy of allogenic
cartilage combined with platelet-rich plasma
(PRP) for physeal repair in a porcine
experimental gap model.
Materials and Methods: The study was carried out in six immature
pigs. Allogenic cartilage was harvested
from low-weight-bearing parts of the femoral
condyle in pigs from the same breed. The
cartilage was frozen and stored.
Preoperatively, autologous venous blood
was drawn from the animal. It was
centrifuged using a commercial PRP kit
(GPS® III, Zimmer Biomet).
Standardized cylindrical defects were
created in both hind legs of all included
animals mimicking a defect after resection
of a physeal bone bridge. The right leg was
randomized for filling with allogenic
cartilage, PRP and Tiseel® (Group A) or
PRP and Tiseel® (Group B). The left leg
received the other treatment. The cartilage
was thawed and rinsed with saline.
Perioperatively, it was cut into small chips of
approximately 1 mm. The cartilage was
blended with the Tiseel® and enriched with
1 mL of PRP. The mixture was inserted into
the empty defect upon randomization. The
contralateral defect was filled with Tiseel®
and enriched with 1 mL of PRP.
All animals underwent MRI scanning at 14
weeks.
Findings / Results: Formation of a bone bridge occurred in one
animal (17%) in Group B. No animals (0%)
formed a bone bridge in Group A. Water-
content MRI showed a mean of 16,7%
higher water-content in Group A compared
to B.
Conclusions: Allogenic cartilage chips can prevent the
formation of bone bridges when combined
PRP and Tiseel®.
The use of allogenic cartilage can spare the
joint cartilage.
52. The effect of load management in adolescents between 10 and 14 years of age with patellofemoral pain – a prospective single-cohort intervention study including 151 adolescents
Michael Skovdal Rathleff, Thomas Graven-Nielsen, Per Hölmich, Lukasz Winiarski, Kasper Krommes, Kristian Thorborg
Research Unit for General Practice in Aalborg, Department of Clinical Medicine, Aalborg University; Center for Neuroplasticity and Pain (CNAP), SMI, Department of Health Science and Technology, Faculty of Medicine, Aalborg University; Sports Orthopedic Research Center-Copenhagen (SORC-C), Department of Orthopaedic Surgery, Copenhagen University Hospital; Department of Occupational Therapy and Physiotherapy, Aalborg University Hospital; Sports Orthopedic Research Center-Copenhagen (SORC-C), Department of Orthopaedic Surgery, Copenhagen University Hospital; Sports Orthopedic Research Center-Copenhagen (SORC-C), Department of Orthopaedic Surgery, Copenhagen University Hospital
Background: Patellofemoral pain (PFP) affects 7% of
adolescents, especially the highly sports
active. Current exercise-focused treatments
are only effective for 30%. Previous
exercise-focused treatments have not
modified and controlled sports activity.
Thus, a different treatment strategy is
warrented as many adolescents continue to
engage in the same high level sports
despite knee pain.
Purpose / Aim of Study: The purpose of this study was to investigate
the effect of a novel treatment strategy
focusing on load management among
adolescents with PFP.
Materials and Methods: This pre-registered prospective cohort study
included 151 adolescents from 10-14 years
of age with PFP. The intervention lasted 12
weeks and included four visits with a
physiotherapist. The intervention included
activity modification (week 0-4) to reduce
loading of the patellofemoral joint using an
activity ladder paradigm including pain
monitoring, progressive home-based
strengthening exercises (week 4-12), and a
progression model for return to sport (week
4-12). Primary outcome was self-reported
recovery at 3 months on a 7-point Likert-
scale ranging from “much improved” to
“much worse”. Adolescents were
considered recovered if they reported “much
improved” or “improved”.
Findings / Results: The median age was 13 years and the
median symptom duration was 18 months.
83% participated regularly in sports while
24% used analgesics for their knee pain at
baseline. At 12 week follow-up, 87%
completed the questionnaire, of which 86%
reported they were recovered and 7% used
analgesics. 90% were satisfied with the
result of the treatment and 95% would
recommend it to a friend.
Conclusions: Activity modification, progressive
strengthening exercises, and return to
sports following a progression model
appears highly effective compared to
previous exercise-focused trials among
adolescents with PFP.
53. Prevention of Bone Bridge Formation using Autologous Cartilage in an Experimental Porcine Model
Ahmed Abdul-Hussein Abood, Bjarne Møller-Madsen, Juan Manuel Shiguetomi-Medina, Hans Stødkilde-Jørgensen, Casper Bindzus Foldager, Ole Rahbek
Children's Orthopaedics, Aarhus University Hospital; Children's Orthopaedics, Aarhus University Hospital; Orthopaedic Research Laboratory, Aarhus University Hospital; MR Center Skejby, Aarhus University Hospital; Orthopaedics, Aarhus University Hospital; Children's Orthopaedics, Aarhus University Hospital
Background: Bone bridges can occur due to physeal
injury. This can lead to partial growth arrest
and bone deformities. The current treatment
is ineffective.
Purpose / Aim of Study: Investigate efficacy of autologous cartilage
for physeal repair in a porcine experimental
gap model.
Materials and Methods: Five immature pigs were included in the
study. At baseline the medial part of the
distal femoral physis was injured in both
legs using a 6 mm cannulated drill. The drill
was inserted 1.5 cm into the bone creating a
standardized gap mimicking a defect after
resection of a physeal bone bridge. The
defects were rinsed with sterile saline. Upon
randomization, the right leg was selected for
either filling of defect with cartilage chips
and Tiseel® (Group A, n =5) or Tiseel only
(Group B, n=5). Cartilage was harvested
from low-weight-bearing parts of the femoral
condyle of the leg randomized for cartilage
treatment. A sharp incision through the skin,
patellar ligament and Hoffa’s fat pad was
made. The articular surface was exposed.
Through two 6 mm punches sites were
designated and harvested. The cartilage
fragments were cut with a scalpel
perioperatively into smallest possible sized
chips. The chips were molted with the
Tisseel® and inserted into the empty defect.
Tiseel® was inserted into the contralateral
empty defect.
The animals were housed for 14 weeks.
MRI was performed at 14 weeks.
Findings / Results: No bone bridges were found on MRI in
Group A. In Group B one case of bone
bridge formation was verified. The water-
content measured on MRI, showed a
greater mean value (9,5%) in Group B.
Conclusions: Bone bridges were prevented when
autologous cartilage chips were added to
the Tiseel®. This suggests that
transplantation of autologous cartilage chips
may play a role in preventing bone bridge
formation.
54. Structural hydroxyapatite tricalciumphosphate graft vs. tricortical iliac crest autograft in paediatric calcaneal lengthening osteotomies. The final results from a randomised controlled noninferiority trial.
Polina Martinkevich, Ole Rahbek, Maiken Stilling, Line Kjeldgaard Pedersen, Martin Gottliebsen , Kjeld Søballe, Bjarne Møller-Madsen
Children's Orthopaedics, Aarhus University Hospital; Children's Orthopaedics, Aarhus University Hospital; Orthopedic Surgery, Aarhus University Hospital; Children's Orthopaedics, Aalborg University Hospital; Children's Orthopedics, Aarhus University Hospital; Orthopaedic Surgery, Aarhus University Hospital; Children's Orthopaedics, Aarhus University Hospital
Background: What if we could avoid donor site pain from harvest
of iliac crest bone graft by using
hydroxyapatitetricalciumphosphate (HATCP) as a
structural bone graft for calcaneal lengthening
osteotomies (CLO) in children?
Purpose / Aim of Study: To compare the structural durability of HATCP to
autologous iliac crest bone graft in CLO for
symptomatic flexible pes planovalgus (FPPV) by
using radiostereometric analysis (RSA).
Materials and Methods: A randomised controlled two-group parallel non-
inferiority design with equal randomisation ratio of
1:1 with one year follow-up.
Patients symptomatic PPV aged between 5-16
years were included. The primary outcome measure
was the stability of the osteotomy, assessed by
RSA. Measurements were obtained on the 1st/2nd
postoperative day, at 6 weeks, 8 weeks, 6 months
and at one year follow-up.
Secondary, the health related quality of life was
assessed by the Oxford Ankle Foot Questionnaire,
before surgery, at 6 months and one year follow-up.
Other outcome measures were the postoperative
pain, analgesics consumption and complications.
Statistics: We would accept the HATCP group to
loose no more than a mean of 2 mm lengthening of
the osteotomy in comparison to the AUTO group at
one-year follow-up.
Findings / Results: There were 7 patients in the HATCP group and 5 in
the AUTO group. One patient was excluded after 8
weeks, due to revisional surgery
The difference in graft compression between the two
groups (HATCP graft compression minus AUTO
graft compression) was 2.02 mm (two-sided 90% CI:
0.73; 3.29).
Both groups showed similar improvement of the
OxAFQ scores at final follow-up. Complications
were more frequently observed in the HATCP group,
Conclusions: We find HATCP to be of limited value as a structural
bone graft for calcaneal lengthening osteotomies in
its current form.
55. Intra-articular vs. Extra-articular Subtalar Arthrodesis: An Assessment of RSA Stability
Peter Buxbom, Stig Sonne-Holm, Christian Wong
Orthopedic Department, Hvidovre University Hospital; Orthopedic Department, Hvidovre University Hospital; Orthopedic Department, Hvidovre University Hospital
Background: The surgical treatment of symptomatic
flexible flatfoot in children depends on the
severity of the malalignment of the hind and
middle foot. The extra-articular subtalar
arthrodesis (EAA) ad modum Grice is
considerably less invasive than the intra-
articular triple arthrodesis (IAA), but is it just
as stable?
Purpose / Aim of Study: To assess the radiostereometric analysis
(RSA) stability of the subtalar fusion in EAA
and IAA.
Materials and Methods: 4-8 markers were inserted in both talus and
calcaneus, which afterwards were used to
analyse the RSA. The children were cast
immobilized for 10 weeks, but allowed
weight-bearing the last 5 weeks within the
cast. RSA follow-up were planned 0, 5, 10
weeks, 6 and 12 months after surgery. RSA
data were valid if CN < 150 and ME <
0.350.
Findings / Results: Eight EAA and 10 IAA were included in the
study. In the analysis of both the EAA and
the IAA group, there were considerable
migration before achieving RSA stability.
One EAA and two IAA remained RSA
unstable until cast removal, but did not
show signs of migration after cast removal.
In this small population we did not see
considerable different healing patterns
between the two groups.
Conclusions: In the included groups we did not see
differences in RSA stability between EAA
and IAA.
56. Validity and Reliability of an Ultrasound Measurement of the free length of the Achilles tendon.
Kristoffer W. Barfod, Anja Falk Riecke, Anders Boesen, Philip Hansen, Jens Friedrich Maier, Simon Doessing, Anders Troelsen
Department of Orthopedics, Clinical Orthopedic Research Hvidovre, Copenhagen University Hospital Hvidovre, Denmark. ; Department of Orthopedics, Copenhagen University Hospital Køge, Denmark.; Institute of Sports Medicine, Copenhagen University Hospital Bispebjerg, Denmark; Department of Radiology, Copenhagen University Hospital Bispebjerg & Frederiksberg, Denmark; Department of Radiology, Copenhagen University Hospital Køge, Denmark; Department of Orthopedics, Copenhagen University Hospital Hvidovre, Denmark. ; Department of Orthopedics, Clinical Orthopedic Research Hvidovre, Copenhagen University Hospital Hvidovre, Denmark
Background: Valid length measurements of the different
segments of the Achilles tendon, that connect
to the three muscle bellies of the triceps surae
are needed in order to investigate if differential
elongation of the Achilles tendon takes place
after rupture.
Purpose / Aim of Study: The purpose of this paper is to present data
concerning accuracy and reliability of an
ultrasound measurement of the free part of the
Achilles tendon.
Materials and Methods: Both legs of 19 non-injured subjects were
examined by MRI and ultrasound. The
length from the distal tip of the soleus
muscle to the tendon insertion on
calcaneus was measured by three
independent ultrasound examiners.
Repeated ultrasound measurements were
performed and compared to MRI
measurements. Intra-rater and inter-rater
reliability and the agreement between MRI
and ultrasound were determined. Data
were evaluated using the Intraclass
Correlation Coefficient (ICC), the Standard
Error of the Measurement (SEM) and the
Minimal Detectable Change (MDC).
Findings / Results: The measurement showed excellent intra-rater
reliability (ICC 0.94 [0.91;0.96], SEM 5mm and
MDC 13mm) and inter-rater reliability (ICC 0.96
[0.93;0.97], SEM 4mm and MDC 11mm).
Ultrasound measurements on average
exceeded the MRI measurements by 2mm
(n.s.); resulting in a measurement error of 5%.
Conclusions: The ultrasound measurement of the free part
of the Achilles tendon showed good reliability
and accuracy. For comparison between groups
of non-injured subjects differences of more
than 5mm can be detected. For repeated
assessment of individual subject differences ≥
13mm can be detected. The US measurement
is a promising clinical tool to be further
assessed in the setting of acute Achilles
tendon rupture.
57. Plantar Forces Mid-Term After Hemiarthroplasty With HemiCAP For Hallux Rigidus
Pernille Henszelman Jørsboe, Michael Stage Pedersen, Mostafa Benyahia, Mads Holm Møller, Thomas Kallemose, Merete Brink Speedtsberg, Hanne Bloch Lauridsen, Jeannette Østergaard Penny
Dept. Of Orthopaedic Surgery, Copenhagen University Hospital at Hvidovre, Denmark; Dept. Of Orthopaedic Surgery, Aleris-Hamlet Hospitaler, Søborg, Denmark; Dept. Of Orthopaedic Surgery, Copenhagen University Hospital at Hvidovre, Denmark; Dept. Of Orthopaedic Surgery, Copenhagen University Hospital at Hvidovre, Denmark; Clinical Research Centre, Copenhagen University Hospital at Hvidovre, Denmark; Human Movement Analysis Lab, 247, Dept of Orthopaedic Surgery, Copenhagen University Hospital at Hvidovre, Denmark; Human Movement Analysis Lab, 247, Dept of Orthopaedic Surgery, Copenhagen University Hospital at Hvidovre, Denmark; Dept. Of Orthopaedic Surgery, Copenhagen University Hospital at Hvidovre, Denmark
Background: Hallux rigidus can be treated with a proximal
hemiarthroplasty (HemiCAP) to preserve motion in
the 1st metatarsophalangeal joint (MTPJ), but the
effect is poorly documented.
Purpose / Aim of Study: We examined the plantar force variables (PFV)
under the hallux the 1st, 2nd, and 3rd – 5 th
metatarsal heads (MH) on patients with HemiCAP
and compared to healthy controls and secondarily
examined the correlations of the PFVs and the 1st
MTPJ range of motion (ROM) and pain.
Materials and Methods: 41 were included, median OP date 2011(2007-
2014), age 63(47-78). ROM measured by both
goniometer and x-ray. Pain by VAS 1-10. Emed
(Novel) Foot Pressure Mapping System measured
peak force (N) and force/time integral (N/s).
Force variables between operated feet and controls
were compared by independent two-sample t-test or
Wilcoxon rank sum test. Force variables association
to ROM and pain by linear regression models.
Findings / Results: HemiCAP/Controls:
Peak force (N): Hallux: 12(1-26)/20(4-30), 1st MH:
17(8-41)/24(14- 42), 2nd MH 24(15-37)/28(24- 37),
3rd-5th MH: 27(18-36)/30(25- 35). Force/time
integral (N/s): Hallux: 1(1- 4)/4(1-12), 1st MH: 5(2-
18)/7(3-11), 2nd MH 8(4-13)/10(7- 13), 3rd-5th MH:
9(6-15)/10(8- 14), (p<0.05 for all). Dorsal ROM of
the operated feet was median 45 degrees (range
10-75) by goniometer and 41 (16-70) by x-ray. An
increase in ROM reduced the PFVs under the
hallux, but not under the MHs. Most patients
reported no pain and no correlation to PFVs were
found.
Conclusions: As expected increased dorsiflexion reduces the
force/time integral, but a mid-term HemiCAP does
not restore the joint motion to normal. Decreased
PFVs under the hallux may reflect a patient
reluctance to load the first ray although plantar
forces were not linked to pain. Most report minimal
pain, but the pain score is biased by missing
numbers and exclusion of revisions.