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DOS Kongressen 2016 ·
119
Occupational and environmental risk factors for
Hip and Knee Osteoarthritis and gene-exposure
interaction: a co-twin control study from the DTR,
DHA and DKA
Søren Glud Skousgaard, Lars Peter Andreas Brandt, Søren Overgaard, Sören
Möller, Axel Skytthe
Department of Occupational and Environmental Medicine, Odense University
Hospital; Department of Orthopaedic Surgery and Traumatology & Orthopedic
Research Unit, Institute of Clinical Research, University of Southern Denmark;
Clinical Institute, University of Southern Denmark; Department of Epidemiology,
Biostatistics and Biodemography, The Danish Twin Registry, University of
Southern Denmark
Background:
No previous studies has examined if genetic factors interacts in
the relationship between causal risk factors and hip and knee OA
Purpose / Aim of Study:
To examine occupational and environmental risk fac-
tors for Hip and Knee OA leading to THA and TKA, and if gene-exposure interac-
tion affects the risk factor-outcome relationships
Materials and Methods:
In October 2012 all twin pairs alive in the Danish
Twin Register (DTR) with at least one in the pair registered in the Danish Hip or
the Danish Knee Arthroplasty Registers (DHA/DKA) with a diagnosis of primary
OA were sent a detailed questionnaire regarding previous occupation, related
exposures and complementary environmental factors. The analyses included
cumulated exposures, McNemar`s X2 tests, and conditional logistic regression
including gene-exposure-interaction variables.
Findings / Results:
1181 twins responded (rate 58.9 %). Responder analyses
did not display any significant difference with non-responders with respect to
diagnosis, zygosity and sex. We found a gene-exposure effect modification in
hip OA-lifting and lifting-walking with OR`s 17.7 (1.1-280.2) and 10.4 (1.00-
107.1), and a clear dose-response relationship between hip OA and prolonged
standing-walking. BMI>25 was a significant risk factor in knee osteoarthritis as
was kneeling, but no gene-kneeling or gene-BMI interaction was detectable
Conclusions:
Gene-exposure effect modification may be important in the de-
velopment of hip OA in particular exposures to lifting and lifting-walking, but
not in knee OA.
No conflicts of interest reported
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