DOS 2017

DOS Kongressen 2017 ·

189

Natural Course of Local Bone Mineralization after

use of a Composite Bone Graft Substitute as Filling

Material for Cavitary Bone Defects. A Prospective

Evaluation using Sequential DXA Measurements

Peter Frederik Horstmann, Werner Hettwer, Michael Mørk Petersen

Department of Orthopedics, University of Copenhagen, Rigshospitalet

Background:

Mineral bone graft substitutes enjoy increasing popularity for a

variety of indications, however, little objective data is available for most of these

products. Dual-energy X-ray Absorptiometry (DXA) is an established method

that allows non-invasive, objective and precise quantification of bone mineral-

ization.

Purpose / Aim of Study:

To objectively quantify changes in bone mineraliza-

tion following bone defect reconstruction using a composite bone graft substi-

tute.

Materials and Methods:

We performed sequential quantitative bone- min-

eral-density (BMD) measurements using DXA in a prospective cohort of 17

patients (F/M: 7/10, mean age 46 (17-69) years)) with 18 bone- defects,

reconstructed with a composite (60% calcium-sulphate/ 40% calcium-phos-

phate) bone- graft-substitute (CERAMENT™|BONE VOID FILLER (BVF) or

CERAMENT™|G, BONESUPPORT AB) following intralesional curettage of benign

bone lesions between July 2014 and March 2016. For comparison, additional

control scans of the opposite extremity were performed after 1 year. Results

are presented as mean (95% Confidential interval).

Findings / Results:

BMD decreased faster in the first 12 weeks (42 mg/cm2/

week), compared to the period between week 12 and 52 (3 mg/cm2/week).

After one year, BMD-values remained 25% (4-47%) higher on the operated

side (p=0.032), when compared to a corresponding area in the contra-lateral

extremity, while no differences were seen, when bilateral areas just adjacent to

the bone defect was compared (p=0.419).

Conclusions:

BMD decreases rapidly during the initial 12 weeks after bone-

defect reconstruction with this particular bone-graft substitute, which is likely

due to expected resorption of its calcium-sulphate component. Subsequently,

the rate of BMD-reduction decelerates, and focal BMD-levels remain at least

equal to or higher than the non-operated side after 1 year.

Conflict of interest:

Peter Frederik Horstmann: BONESUPPORT AB, Sweden

141.