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· DOS Abstracts
Selective Serotonin Reuptake Inhibitor Use among Hip
Fracture Patients: A Danish nationwide cohort study,
2006-2012
Stine Bakkensen Bruun, Irene Petersen, Deirdre Cronin-Fenton, Alma Becic Ped-
ersen
Department of Clinical Epidemiology, Aarhus University Hospital; Department
of Primary Care and Population Health, University College of London; Depart-
ment of Clinical Epidemiology, Aarhus University Hospital; Department of Clini-
cal Epidemiology, Aarhus University Hospital
Background:
Hip fracture is a common trauma associated with high morbidity
and mortality. 1/3 of hip fracture patients have at least one chronic comorbid
condition and receive multiple prescription medications. Depression is common
in elderly patients and despite concerns regarding adverse effects, selective se-
rotonin reuptake inhibitors (SSRI) are prescribed as first choice treatment.
Purpose / Aim of Study:
To examine the prevalence of SSRI use among elderly
hip fracture patients in Denmark during 2006-2012 and to identify factors as-
sociated with SSRI use.
Materials and Methods:
We conducted a nationwide cohort study. During
2006-2012 hip fracture surgery patients aged ≥65 years were identified using
the Danish Multidisciplinary Hip Fracture Database. We tabulated patient char-
acteristics by SSRI status. The association between patient characteristics and
SSRI use were estimated as prevalence risk ratios (PRR) with 95% confidence
interval (CI) using Poisson regression analyses. Comorbidity was assessed using
the Charlson Comorbidity index (CCI).
Findings / Results:
Among 44,788 patients, 27.29% redeemed at least one
prescription for SSRI’s within two years prior to surgery. The prevalence of SSRI
use decreased from 27.68% (CI 26.57%-28.81%) in 2006 to 25.27% (CI
24.19%-26.37%) in 2012. Factors associated with SSRI use were female gen-
der (PRR = 1.15; CI 1.10-1.19), age between 75-84 and above 85 years (PRR
= 1.10; CI 1.04-1.16 and PRR = 1.11; CI 1.05-1.17 respectively), CCI medium
(score 1-2) (PRR = 1.34; CI 1.28-1.40) and CCI high (score >=3) (PRR = 1.42;
CI 1.35-1.50).
Conclusions:
More than 1/4 of Danish hip fracture patients had a prescription
for SSRI although the use is decreasing. Female gender, older age and higher CCI
score were associated with SSRI use. Our data can provide a basis for improving
the safety of SSRI use in elderly hip fracture patients.
No conflicts of interest reported
16.