DOS 2017

· DOS Abstracts

Treatment of Osteoarthritis with the Stromal Vascular

Fraction of Abdominal Adipose Tissue - a Pilot Study

Kristoffer Weisskirchner Barfod, Lars Blønd

Dept. of Orthopedic Surgery, Zealand University Hospital

Background:

Treatment of knee osteoarthritis (OA) with minimally manipulat-

ed cell therapies have gained increasing popularity. The stromal vascular fraction

of abdominal Adipose tissue (SVF) is a rich source of mesenchymal stem cells.

Studies using SVF have shown promising results.

Purpose / Aim of Study:

To investigate the feasibility and safety issues of

treatment of knee OA with intra-articular injection with SVF harvested and pre-

pared using the Lipogems System.

Materials and Methods:

The study was performed as a prospective cohort

study with follow up after 3, 6 and 12 months. Primary endpoint was any ad-

verse event at 3 months. Secondary endpoint was KOOS. Patients aged 18-70

years were eligible for inclusion if they had been diagnosed with osteoarthritis.

Exclusion criteria were malalignment of the knee > 5 degrees, instability or BMI

> 35. SVF was harvested through two stab incision just below the umbilicus and

prepared for implantation using the Lipogems system; an enzyme-free technol-

ogy that works through a mild mechanical tissue cluster size reduction. Implan-

tation of 8- 16ml SVF in the knee was performed using a 21 gauge syringe.

Findings / Results:

20 patients were included and 19 participated in follow

up. Mean (SD) age was 49 (9), weight 89kg (22), height 170cm (23). One

adverse event was registered as a patient complaint of cosmetically changes to

the abdominal subcutaneous tissue. 13 of 19 would go for the procedure again.

At 3 months KOOS Pain increased 9 (p=0.003) points, Symptoms 4 (p=0.197),

ADL 9 (p=0.008), Sport 13 (p=0.002) and QOL 15 (p=0.008). Differences

dropped to border significant values at 6 and 12 months.

Conclusions:

Treatment of knee OA with intra-articular injection with SVF har-

vested and prepared using the Lipogems System is feasible and safe. Efficiency

of the treatment is questionable and is not evaluated in the present study.

No conflicts of interest reported

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