113 / 245
DOS Kongressen 2016 ·
113
Safe Performance of E-vitamin Infused Polyethylene in
Total Knee Arthroplasty at 3-year Follow-up Evaluated
in a Prospective, Multicenter Study.
Timothy Hunt Batter, Christian Skovgaard Nielsen, Vincent Galea , Huddleston
James , Henrik Malchau, Anders Troelsen
The Harris Orthopaedic Laboratory, Orthopaedic Department, Massachusetts
General Hospital, Boston, USA ; Department of Orthopaedic surgery , University
Hospital Hvidovre, Copenhagen, Denmark; The Harris Orthopaedic Laboratory,
Orthopaedic Department, Massachusetts General Hospital, Boston, USA ;
Department of Orthopaedic Surgery, Stanford University Medical Center, Stanford,
California, USA; The Harris Orthopaedic Laboratory, Orthopaedic Department,
Massachusetts General Hospital, Boston, USA ; Department of Orthopaedic surgery
, University Hospital Hvidovre, Copenhagen, Denmark
Background:
E-vitamin infused polyethylene is expected to have reduced rate of
wear in TKA due to anti-oxidant effects compared to highly crosslinked polyethyl-
ene. This is supported by in vitro TKA studies and clinical studies in THA, however
never evaluated in vivo for TKA.
Purpose / Aim of Study:
The aim of this prospective multicenter study was to
investigate E-vitamin infused polyethylene used in TKA after 3 years for 1) risk
potential to develop osteolytic lesions and radiolucent lines as measured by radio-
logical assessment and 2) the quality of life and functionality as measured by patient
reported outcome measures (PROMs).
Materials and Methods:
499 patients from centers in Europa, USA, Asia and
Australia received TKA. Surgery was performed from January 2011 to December
2014. Demographic data, postoperative radiographs, and PROMs were collected at
3 years ± 6 months. Radiological analysis was performed according to outlined by
the American Knee Society (AKS) for radiolucency and osteolytic lesions. PROMs
measured the clinical outcomes (KOOS, UCLA, AKS and EQ5D score).
Findings / Results:
For the 127 patients who received 3 year radiographs, 73.4%
were females, mean BMI was 30.4 (SD ± 6.7), and mean age was 63 (SD ± 8.6).
80.7% of patients had no signs of radiolucent lines in any of the AKS zones. For radi-
olucent lines, 15.0% and 3.4% had a maximal depth between 1-2mm, and 2-3mm,
respectively. 1.3% had osteolytic lesions, however no osteolytic lesions extending
into adjacent zones. PROMs demonstrated high performance for UCLA, AKS knee,
and all KOOS subscales scores regarding functionality, and for EQ5D regarding life
quality. 3 patients were revised due to sepsis and early instability.
Conclusions:
E-vitamin infused polyethylene showed low rate of complications and
osteolytic potential at this 3-year follow-up study.
No conflicts of interest reported
64.