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· DOS Abstracts
One-year incidence of prosthetic joint infection in
total hip arthroplasty: a cohort study with linkage
of the Danish Hip Arthroplasty Register and Danish
Microbiology Databases
Per Hviid Gundtoft, Alma Pedersen, Henrik Carl Schønheyder, Jens Kjølseth
Møller, Søren Overgaard
1. Ortopædkirurgisk Afd., Kolding 2. Ortopædkirurgisk Afd. Odense, 1. Kolding
Sygehus, 2 OUH; Klinisk Epidemiologisk Afdeling, Aarhus; Klinisk Mikrobiologi,
Aalborg; KliniskMikrobiologi, Vejle-endel af sygehus Lillebælt;Ortopædkirurgisk,
Odense Universitetshospital
Background:
To examine the change in rate of prosthetic joint infections (PJI)
following primary total hip arthroplasty (THA) during the period 2005-2014
and the antimicrobial resistance of the bacteria causing these infections.
Purpose / Aim of Study:
To examine the change in rate of prosthetic joint
infections (PJI) following primary total hip arthroplasty (THA) during the period
2005-2014 and the antimicrobial resistance of the bacteria causing these in-
fections.
Materials and Methods:
We identified a population-based cohort of patients
in the Danish Hip Arthroplasty Register (DHR) who had primary THA and re-
ceived their surgery in Jutland or Funen between 2005 and 2014. We followed
the patients until revision, death, or up to one-year of follow-up. Data from
the DHR were combined with those from microbiology databases, the National
Register of Patients, and the Civil Registration System. We estimated the cu-
mulative one-year incidence of PJI for two 5-year periods; 2005-2009 and
2010- 2014. The hazard ratio of PJI as a measure of relative risk after adjusting
for multiple risk factors was calculated.
Findings / Results:
Of 48,867 primary THAs identified, 1,120 underwent re-
vision within one year. Of these, 271 were due to PJI. The incidence of PJI was
0.53% (95% CI: 0.44; 0.63) during 2005-2009 and 0.57% (95% CI: 0.49;
0.67) during 2010-2014. The adjusted relative risk was 1.05 (95% CI: 0.82;
1.34) for the 2010-2014 period versus the 2005-2010 period. The most
common micro-organisms identified in the 271 PJI were Staphylococcus aureus
(36%) and coagulase-negative staphylococci (33%); Antimicrobial resistance to
beta-lactams and gentamicin did not change during the study period.
Conclusions:
The risk of PJI within one-year after primary THA and the anti-
microbial resistance remained unchanged during the 2005-2014 study period.
No conflicts of interest reported
129.