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· DOS Abstracts
Long-term Survival after Surgical Treatment of Spinal
Metastasis – The Predictive Role of Gender
Dennis Karimi, Søren Morgen, Sidsel Fruergaard, Martin Gehrchen, Benny Dahl
Spine Section, Dept. of Orthopeadic Surgery, Rigshospitalet
Background:
Numerous pre-operative scoring systems based on clinical and
imaging variables have been suggested to predict long-term survival in patients
undergoing surgical treatment for symptomatic spinal metastasis, but the pos-
sible role of gender as an independent predictor of long-term survival has not
been reported in studies with long time follow-up. Since 2005, Rigshospitalet,
has been responsible for the treatment of patients with acute symptoms of
spinal metastasis and serves as a referral unit for the Eastern half of the coun-
try. This organization makes it possible to follow a large group of patients with
MSCC and to follow long-term outcomes.
Purpose / Aim of Study:
To examine whether gender predicts long term sur-
vival in patients with symptomatic spinal metastasis after surgical treatment.
Materials and Methods:
A prospective database including all patients referred
with acute symptoms of spinal metastasis was established in 2005. Relevant
variables were registered at referral including age, gender, and primary onco-
logic diagnosis. From January through December 2015 the survival status of all
patients was obtained through the Central Office of Civil Registration.
Findings / Results:
A total of 58 patients were operated for MSCC in 2005.
The average age of the patients was 63 years and 55% were males. At the
ten years follow-up 55 patients had died and the average survival time af-
ter surgery was 20 months. Survival time was significantly longer for females
compared to males; 32 vs. 10 months (P<0.05). The hazard-ratio of 10- years
survival for females was 2.12 (P< 0.01). This difference remained significant
after adjusting for specific primary tumors and operation-age.
Conclusions:
In spite of the small sample size, these results could indicate that
gender should be included in pre- operative scoring systems used for patients
with spinal metastasis.
No conflicts of interest reported
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