DOS 2017

DOS Kongressen 2017 ·

121

Association between periacetabular osteotomy (PAO)

and the occurrence of hip dysplasia in among relatives

of Danish patients – a cross-sectional study.

Pernille Simonsen, Jens Michael Hertz, Kjeld Søballe, Inger Mechlenburg

Orthopaedic Surgery, Aarhus Universitetshospital; Human Genetic, Odense Uni-

versitetshospital; Orthopaedic Surgery, Aarhus Universitetshospital; Orthopae-

dic Surgery, Aarhus Universitetshospital

Background:

Background: Studies indicate that the risk of hip dysplasia is in-

creased in cases where relatives suffer from PAO, especially first- degree rela-

tives.

Purpose / Aim of Study:

Purpose: The aim of this study is thus to investigate

the association between uni- or bilateral PAO, the occurrence of hip dysplasia

within the family, and the degree of family relations.

Materials and Methods:

Material and Method: This cross-sectional study

consists of 815 consecutive PAO patients treated from 1998 to 2016. The

information about gender, uni- or bilateral PAO and age at the time of surgery

was obtained from the clinical PAO database at Aarhus University Hospital. In-

formation about the occurrence of hip dysplasia within the family familial was

collected through questionnaires. The association was assessed by using logistic

regression analysis, and was divided into 615 unilateral and 200 bilateral PAO

patients.

Findings / Results:

Results: Patients, who have first-degree relatives with hip

dysplasia, had a 72% (OR= 1.72, 95% CI 1.17; 2.50) higher occurrence of bilat-

eral PAO than patients without familial occurrence of hip dysplasia. This associa-

tion was statistically significant (p=0.005), even when adjusting for gender and

age at the time of surgery. Corresponding association was not shown among

any other degree of relationship.

Conclusions:

Conclusion: Danish patients with hip dysplasia who have first-de-

gree relatives with hip dysplasia have increased odds of being surgically treated

for bilateral PAO compared to patients without relatives with hip dysplasia. In

other words having bilateral PAO indicates a greater likelihood of hip dysplasia

being hereditary. Thus, this study reveals a potential new target group where

genetic investigation may identify individuals with higher risk of hip dysplasia.

No conflicts of interest reported

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